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Because your needs can change quickly, we maintain a fully stocked inventory
of chiral columns and
CSPs, all ready to be
shipped within 24
hours of your order. |
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| SMB is typically used for larger scale separations, usually starting from a few kg up to 50 kg. Although the development of a SMB process takes longer than for a HPLC or SFC method, the SMB system uses both the chiral stationary phase and the mobile phase much more efficiently,
resulting in a higher rate of productivity and lower solvent cost. SMB separations at CHIRAL TECHNOLOGIES can be carried out under cGMP. |
| Method development |
| SMB is the process used for the production scale chromatographic purification of enantiomers. The separations developed for small-scale units can be used with a high degree of reliability to predict the performance of the production units.
For this reason, we have implemented a SMB method development service, in which we screen a sample destined for large-scale production across our proprietary CSP library to determine the optimum conditions for SMB separations. |
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| In-house SMB methodology |
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| From these data we run computer simulations to obtain a first estimate of costs which can be used to determine if the process could be economic. After this is established, we use a bench-top unit
to confirm the computer predictions and to finalize the optimization experimentally. These results can be used to predict exactly the operating parameters of a production scale SMB unit. |
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| Finally, a pilot-scale separation is run using our lab SMB unit. |
| Commercial-scale SMB |
| Once your project is ready, we help you decide the best way to proceed with scale-up to commercial production:
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