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| The Custom Separation Services of CHIRAL TECHNOLOGIES has been in operation for many years and is well established and well known. We offer separation services on a preparative scale in HPLC, SFC, and SMB modes. |
| Complete confidentiality |
- Establishing a confidentiality agreement allows us to share information while preserving the intellectual property of our customer and that of CHIRAL TECHNOLOGIES and Daicel.
- A project starts by gathering information about the product, its properties (structure, solubility, safety, what separations have already been tried) and about the needs
(quantity, time scale, final product specification).
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| Product screening |
- Starting with a small quantity of racemate (~200 mg) we carry out a free screening on the product for separation using the preparative scale CSPs available to us.
- The screen, carried out using both HPLC and SFC, usually results in a promising separation which is then optimized to give the best preparative separation method.
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| Loading study |
- Once the separation is optimized, we carry out a loading study to determine the production rate possible for the range of techniques available,
and to isolate a small quantity of one or both enantiomers for stability testing.
- With all the information in hand, we then prepare a quotation for the quantity of product required. Once this is approved and the order is placed,
we commence the project, returning the purified enantiomers within the agreed time frame.
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| Analysis completion |
- The final products are returned to you accompanied by a Certificate of Analysis. For all cGMP projects, CHIRAL TECHNOLOGIES adheres to the ICH Q7A, paragraph 19 guidelines.
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