West Chester, PA– June 28, 2007– Daicel Chemical Industries, Ltd. and Groupe Novasep, announced the formation of a strategic technical co-operation aimed at streamlining the use of chiral chromatography for manufacturing late-stage clinical and commercial chiral intermediates and APIs.

Under the terms of the agreement, the companies will cooperate to develop the most time and cost effective solution for the manufacture of chiral compounds for customers in the pharmaceutical and custom manufacturing industry. Daicel and its subsidiaries Chiral Technologies Europe, SAS and Chiral Technologies Inc. will identify the best chiral stationary phase from their extensive library of commercial and developmental chiral stationary phases (CSP’s). Novasep Process will provide process optimisation services, using its unique computer simulation software and full process development with its advanced technologies such as Varicol? continuous chromatography process. The intended result of this combined approach is to deliver guaranteed scale-up, optimum performance and best economics for large-scale separations.

“Today, several chiral drugs are commercially produced at tons to 100’s tons scale with chromatographic technologies. Such drugs include Pfizer’s Zoloft, UCB Pharma’s Keppra, Lundbeck’s Lexapro/Cipralex and Cephalon’s Nuvigil” said Jean Blehaut, President of Novasep Process’ Pharma Business Unit. “But the pharmaceutical industry is just discovering the potential of chiral chromatography to bring NCEs to the market faster. The existing commercial projects have demonstrated that it is often cheaper to produce single enantiomeric drugs with chromatography rather than use traditional technologies such as crystallization and/or asymmetric synthesis. Jean Blehaut continued, “the time is right to join forces in the field of large scale chiral chromatography to more rapidly develop this technology for the industry”.

“The idea of our cooperation is quite simple; we are proposing to our current and future customers the option to obtain all the required process and method data whilst maintaining the single point of contact of their choice, either Novasep or Daicel.”, stated Dieter Heckmann, CEO of Chiral Technologies Inc and Chiral Technologies Europe. “Each company will apply its core technical skills to develop a single solution to meet each project’s short and long-term objectives.”

The customer will be presented with the combined data to make an informed decision. A production process (chromatographic system and CSP) will include all applicable licenses to Novasep and Daicel’s extensive intellectual property.”.

Daicel Chemical Industries Ltd. is a leading supplier of chemical products and technologies to industry with a turnover in 2006 of ca. 2.9 billion USD.

Daicel’s CPI division is the world leader in the development and manufacture of chiral stationary phases for enantiomer separation. In combination with a network of Chiral Technology Laboratories, which have in excess of 20 years experience in the manufacturing of stationary phases and an extensive knowledge in large-scale chiral separations, Daicel ensures global support for the isolation of chiral pure compounds, (Chiral Technologies Inc., USA, Chiral Technologies Europe SAS, Daicel Chiral Technologies China and Daicel Chiral Technologies India).

The Chiral Technology laboratories offer local technical assistance, supply from stock and complimentary support services to ensure the growth in use of chiral chromatography in the pharmaceutical and biotechnology industries.

Daicel products are the industry leading chiral chromatographic phases and are used in the majority of pharmaceutical laboratories and production plants worldwide.

Novasep Process specialises in solving purification challenges for the Pharmaceutical, Biopharmaceutical and Industrial Biotech markets. The company offers laboratory purification equipment as well as large-scale industrial production plants for producing pure products, and a full range of services including process development, multi-ton scale custom purification and performance optimisation.

Groupe Novasep covers the special needs of the pharmaceutical, food, cosmetics, agrochemicals, and specialty chemicals industries. It combines chemical synthesis and chemical engineering expertise in order to develop new technologies. The group operates through two divisions: Novasep Synthesis and Novasep Process focusing on the synthesis and process of intermediates, advanced intermediates and APIs.

For more information please visit Novasep website www.novasep.com
or contact:

Jean-Marc Le Rudulier
Marketing & Communication Director
Groupe Novasep
Telephone: + 33 (0)3 83 49 71 4

For more information please visit the Chiral Technolgies website www.chiral.fr / www.chiraltech.com or contact:

Frédéric Cheviron
Marketing Manager
Chiral Technologies Europe
Telephone: + 33 (0)3 88 79 20 00

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