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Because your needs can change quickly, we maintain a fully stocked inventory
of chiral columns and
CSPs, all ready to be
shipped within 24
hours of your order. |
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| Chiral stationary phases (CSPs) available from Daicel are based upon chiral selectors produced by derivatization of amylose or cellulose polymers. The product range available from Daicel
may be divided into two distinct groups: modern, immobilized phases and traditional, coated phases. Literature reports that 85% of chiral separations have been achieved on these CSPs which show an extremely wide range of applicability.
The key to this success is the number of different stationary phases available and the dramatic effect of changing mobile phases. |
| Immobilized phases.The immobilized phases, namely CHIRALPAKŠ IA™, CHIRALPAK IB™, and CHIRALPAK IC™, constitute the "Platinum Series" columns. CHIRALPAK IA and CHIRALPAK
IB are based upon the 3,5-dimethylphenylcarbamate derivatives of amylose and cellulose respectively, which are immobilized on 5-micron silica. CHIRALPAK IC has a unique chiral selector, cellulose tris 3,5-dichlorophenylcarbamate, which
brings a new separation capability to the polysaccharide phases. Preparative versions of two of these phases, CHIRALPAK IA and CHIRALCEL OD-I (equivalent to CHIRALPAK IB), based on 20-micron silica, are also available. The designation
of the latter phase is changed since this CSP uses an immobilization technique a little different from that used for CHIRALPAK IB. |
Coated phases. The original Daicel CSPs were formed by coating the chiral polymer from the derivatization of the amylose and cellulose on 10-micron diameter silica. Subsequently, CHIRALPAK AD , CHIRALPAK AS, CHIRALCEL OD,
CHIRALCEL OJ, CHIRALCEL OB, and CHIRALCEL OC have now been effectively superseded by products made with higher-efficiency 5-micron particles. These CSPs are designated AD-H, AS-H, OD-H,
OJ-H, OB-H and OC-H. Because these CSPs are made by coating the polymer on the silica, any solvent that will dissolve the polymer will remove the coating and damage the CSP. For this reason there are strict limits on the mobile phases that may be
used and one of Daicel's priorities is to develop further the range of immobilized CSPs to eliminate these restrictions. |
| Structures of commercially available polysaccharide CSPs |
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